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Postdoctoral Appointee, Department of Emergency Medicine

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Indiana University
Location: Indiana, Pennsylvania
Category: Admin-Other Administrative Positions
Posting Date: 07/20/2023
Application Deadline: Open until filled

Job Description

Posting Details
Position Details

Title	Postdoctoral Appointee, Department of Emergency Medicine
Specific Title	Postdoctoral Appointee-Blood Coagulation/Fibrinolysis Research: Pharmaceutical Development
Appointment Type	Postdoctoral Fellow
Department	IUSM - Emergency Medicine
Campus	IU School of Medicine Indianapolis
Position Summary	The laboratory of Dr. Nathan J. Alves, PhD, within the Department of Emergency Medicine at the Indiana University School of Medicine (IUSM), is seeking a highly motivated and independent post-doctoral research fellow. Dr. Alves is a Chemical and Biomolecular Engineer, Associate Professor and the Director of Translational Research for the Department of Emergency Medicine in addition to having a faculty appointment at Purdue University in Biomedical Engineering. The Alves Lab explores highly interdisciplinary research interests applying engineering and biophysical principles and designs to create translational technologies and treatments in the area of blood coagulation and fibrinolysis. The primary focus of research in the laboratory is to develop targeted clot digesting therapeutic agents to more safely digest clinically relevant blood clots to treat pulmonary embolism (PE, blood clots in the lungs), deep vein thrombosis (DVT), and ischemic stroke. This interdisciplinary research utilizes diverse enzyme assays, chemical synthesis, blood clot formation and digestion assays under shear, and other novel testing/delivery platforms that include multivalent branched molecules and nanoparticle drug delivery systems. Projects Include: (1) Leveraging multivalency to modulate enzyme activity and improve inhibitor selectivity (nanoparticle drug delivery and targeting). (2) Ex-vivo flowing models of clot digestion under shear using in-vivo like fluorescently labeled blood clots from human whole blood. (3) Development of novel fibrinolytic diagnostics tools to assess coagulation state. (4) Mouse models of clot formation/targeting/digestion utilizing intravital microscopy. (5) Study the effects of environmental microplastic exposure on coagulation/fibrinolysis. Projects are funded both externally and internally. Indiana University School of Medicine (IUSM) has nine campuses across the state and educates the largest medical student body in the U.S. As the nation’s largest medical school, IUSM is committed to being an institution that not only reflects the diversity of the learners we teach and the patient populations we serve, but also pursues the values of diversity, equity, and inclusion that inform academic excellence. We desire candidates who enhance our representational diversity, as well as those whose work contributes to equitable and inclusive learning and working environments for our students, staff, and faculty. IUSM strives to take an anti-racist stance, regularly evaluating and updating its policies, procedures, and practices to confer equitable opportunities for contribution and advancement for all members of our community. We invite individuals who will join us in our mission to advance racial equity to transform health and well-being for all throughout the state of Indiana. Indianapolis is the capital and most populous city in the State of Indiana. It is growing economically thanks to a strong corporate base anchored by the life sciences. Indiana is home to one of the largest concentrations of health sciences companies in the nation. Indianapolis has a sophisticated blend of charm and culture with a wonderful balance of business and leisure. The growing residential base is supported by rich amenities and quality of life – the city possesses a variety of professional sports, arts venues, and outdoor recreation areas. Residents of this dynamic city, and surrounding suburbs, enjoy leading educational systems and top-ranked universities, paired with a diverse population. Indianapolis International Airport is a top-ranked international airport, being named “Best Airport in North America” by Airports Council International for many years. For additional information on life in Indy: https://faculty.medicine.iu.edu/relocation.
Basic Qualifications	Ph.D. or equivalent terminal degree in biomedical engineering, bioengineering, chemistry, biochemistry, or cell and molecular biology. Experience with chemical synthesis such as solid phase peptide synthesis (SPPS), click chemistry, and amine reactive chemistries. Experience with enzyme kinetic and inhibition assays in addition to basic molecular biology methods. Experience with analytical techniques such as: UV/VIS and fluorescence spectrophotometry, High Performance Liquid Chromatography (HPLC), and mass spectrometry. Experience with handling blood performing blood coagulation/fibrinolysis assays including use of analysis tools such as thromboelastography (TEG), Chandler Loop apparatus clot formation, and fluorescence microscopy are desirable but not necessary. Excellent written and oral communication skills in English. Motivated, self-driven, and able to work independently with limited direct supervision. Able to multitask and show interest in contributing to several projects ongoing in the lab. Interested in collaborating with other members of the laboratory. Will be expected to write manuscripts and give regular presentations within the lab. Will be expected to present at scientific meetings and conferences. Over time, may be expected to work with and mentor students from various levels of training.
Department Contact for Questions	Nathan J. Alves, Ph.D. Director of Translational Research nalves@iu.edu
Additional Qualifications
Special Instructions	Screening of applications will begin immediately and the position will remain open until filled. Please be prepared to upload: A CV, Letter of interest (in this document please be sure to include a brief description of research interests and past research experience), and the names and contact information for three references.
Priority Application Review Deadline
Expected Start Date	09/01/2023
OAA #	IUSM-01748-2023

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